References

Accuryn’s ™ clinical and commercial value is supported by external research and clinical studies performed by leading researchers, healthcare provider organizations, foundations, and government agencies.

Key References:

Ryotaro Kato and Michael R. Pinsky, Personalizing blood pressure management in septic shock”Annals of Intensive Care 2015, 5:41  doi:10.1186/s13613-015-0085-5

Automated, accurate urine output and intra-abdominal pressure monitoring can be used to personalize blood pressure management for critically ill patients to avoid damage to organs from over or under resuscitation.

Henry KE, Hager DN, Pronovost PJ, Saria S “A targeted real-time early warning score (TREWScore) for septic shock”, Published 5 August 2015, Sci. Transl. Med. 7, 299 (2015)

13,014 patient study on Sepsis showed that urine output was more useful than SIRS criteria themselves.

Additional References:

  • Center for Medicare and Medicaid Services, Fact Sheet SEP-1: Early Management Bundle, Severe Sepsis/Septic Shock, October 2015
  • Martin, Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes Expert Rev Anti Infect Ther. 2012 June ; 10(6)
  • Shorr AF, Micek ST, Jackson WL, Jr., Kollef MH: Economic implications of an evidence-based sepsis protocol: can we improve outcomes and lower costs? Crit Care Med 2007, 35(5):1257-1262.
  • Kumar G, Kumar N, Taneja A, et al. Nationwide trends of severe sepsis in the 21st century (2000-2007). Chest 2011;140:1223-1231
  • Shaefi et. Al, “Effect of Cardiogenic Shock Hospital Volume on Mortality in Patients With Cardiogenic Shock” Journal of the American heart Association (2015)
  • Vaara et al., “Fluid overload is associated with an increased riskfor 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study”, Critical Care 2012, 16:R197
  • Society for Critical Care medicine http://www.sccm.org/Communications/Pages/CriticalCareStats.aspx
  • Leite T et al. Timing of renal replacement therapy initiation by AKIN classification system Critical Care 2013, 17:R62
  • Mandelbaum, T; Scott, DJ; Lee, J; Mark, RG; Malhortra, A; Waiker, SS; Howell, MD; Talmor, D (December 2011). “Outcome of critically ill patients with acute kidney injury using the AKIN criteria”. Critical Care Medicine 39 (12): 2659–64.
  • Magee, G, et al, “Fluid overload is associated with increases in length of stay and hospital costs: pooled analysis of data from more than 600 US hospitals”, ClinicoEconomics and Outcomes Research, 26 June 2013 Volume 2013:5 Pages 289—296
  • Dellinger R, Levy M, Rhodes A. “Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock”, 2012. Intensive care Medicine 2013.
  • Pinsky, M, “Functional Hemodynamic Monitoring”, Critical Care 2005, 9:566-572
  • Grossini E et al. Levosimendan Protection against Kidney Ischemia/Reperfusion Injuries in Anesthetized Pigs, The Journal of Pharmacology and Experimental Therapeutics 2012, 342(2), 376-388.
  • Shamir, et al, “Urine flow is a novel hemodynamic monitoring tool for the detection of hypovolemia”, Anesth Analg. 2011 Mar;112(3):593-6
  • Khosravi, et al, “The effect of clamping of inferior vena cava and portal vein on urine output during liver transplantation”, Transplant Proc. 2007 May;39(4):1197-8.
  • Cheatham, ML, “Intraabdominal pressure monitoring during fluid resuscitation”, Current Opinion in Critical Care 2008, 14:327
  • Connor, M, American Society of Nephrology, Presentation on Abdominal Compartment Syndrome, Critical Care Nephrology: 2015 Update
  • Danek, Gale, et al. “Prevalence of Dependent Loops in Urinary Drainage Systems in Hospitalized Patients.” Journal of Wound Ostomy & Continence Nursing 42.3 (2015): 273-278.
  • Garcia, M, et al, “Traditional Foley drainage systems–do they drain the bladder?”, J Urol. 2007 Jan;177(1):203-7
  • Drewry A, Fuller B, Bailey T, Hotchkiss R. Body temperature patterns as a predictor of hospital-acquired sepsis in afebrile adult intensive care unit patients: a case-control study. Crit Care. 2013.
  • Drvar Željko, Mirić Mirjana, Pavlek Mario, Baronica Robert, Bandić-Pavlović Danijela, Perić Mladen. Correlation between intra-abdominal hypertension and arterial lactate concentration in severe sepsis patients. Signa Vitae 2014; 9 (Suppl 1):25 – 28
  • Malbrain, et al. Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Medicine. 2004; 30:822-829.
  • Beeckman, et al, “A systematic review and meta-analysis of incontinence-associated dermatitis, incontinence, and moisture as risk factors for pressure ulcer development”, Res Nurs Health. 2014 Jun;37(3):204-18. doi: 10.1002/nur.21593. Epub 2014 Apr 3.
  • Hooton, et al, “Diagnosis, Prevention, and Clinical Practice Guidelines from the Infectious Diseases Society of America”, Clinical Infectious Diseases 2010; 50:625–663
  • IPPS/LTCH PPS final rule (p. 50236) https://www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/AcuteInpatientPPS/FY2015-IPPS-Final-Rule-Home-Page-Items/FY2015-Final-Rule-Regulations.html
  • Felix, K, et al, “Guide to Preventing Catheter-Associated Urinary Tract Infections”, Association for Professionals in Infection Control (APIC) and Epidemiology Guidelines, 2014